کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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4351645 | 1298072 | 2011 | 7 صفحه PDF | دانلود رایگان |
Exposure to novelty, a mild psychological stressor, induces neuronal activations in the hippocampus of rodents, which may play an important role in the adaptation to stress. We examined the changes in three parameters, i.e., gene expression in the hippocampus using a RT-PCR method, corticosterone and motor activity, in mice exposed to a new environment for 120 min. A sharp and short-lasting increase in the gene expression of a set of stress-related genes previously reported, e.g., Fos and Nr4a1, was observed during the stress, with a similar pattern of changes in corticosterone. The motor activity gradually decreased during the novelty stress, indicating a process of adaptation to the new environment. In addition, in order to minimize the effects of elevated adrenal hormones by the stress, we carried out experiments on adrenalectomized (ADX) mice. However, the adrenalectomy produced minimal changes in the pattern and the magnitude of the gene response after the stress, while the motor activity showed a relatively slower pattern of adaptation in the ADX mice. Hence, the present study suggests that there was a coordinated adaptation process to the new environment in mice, and that the transcriptional response was mediated by neuronal networks rather than by adrenal hormones.
• An effect of exposure to a new environment was examined in mice.
• A sharp and short-lasting increase was observed in the hippocampal gene expression.
• Levels of corticosterone and motor activity showed a process of adaptation to novelty.
• Adrenalectomy produced minimal changes in the transcriptional response to the stress.
• The coordinated molecular response of adaptation may be mediated by neuronal-networks.
Journal: Neuroscience Research - Volume 71, Issue 2, October 2011, Pages 161–167