کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4352521 | 1298120 | 2010 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Immunohistochemical study of vesicle monoamine transporter 2 in the hippocampal formation of PCP-treated mice
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کلمات کلیدی
PCPNMDAN-methyl-d-aspartateCOCVMAT2stratum radiatum - stratat radiatumSchizophrenia - اسکیزوفرنی یا شیزوفرنیImmunohistochemistry - ایمونوهیستوشیمیcornu ammonis - بال آمونSra - خانمMethamphetamine - متیل آمفتامینAnimal model - مدل حیوانیmap - نقشهHippocampus - هیپوکامپ personal computer - کامپیوتر شخصیCocaine - کوکائین
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
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چکیده انگلیسی
The exact pathophysiology of schizophrenia is unknown despite intensive scientific studies using molecular biology, psychopharmacology, neuropathology, etc. It is thought that neurodevelopmental failures such as neuronal network incompetence and the inappropriate formation of neurons affect the neurotransmitters. Several animal models have been created to investigate the etiology of this disease. In this study, we investigated the expression of vesicle monoamine transporter 2 (VMAT2), which has a significant role in neurotransmission, in the hippocampal formation in 1-phenylcyclohexylpiperazine (PCP)-treated mice using immunohistochemical staining technique to clarify neuronal abnormalities. PCP-treated mice are thought to be one of novel animal models for schizophrenia. The expression of VMAT2 in the hippocampal formation was significantly reduced overall in the PCP-treated mice compared to that in control (saline-treated) mice, also these reductions were observed throughout the brain. These facts implied that the pathophysiology of this disease involves abnormal monoaminergic transmission through VMAT2, despite PCP was the N-methyl-d-aspartate (NMDA) receptor antagonist that might induce glutamatergic abnormality. Since insufficient or excess release of neurotransmitter might alter neurochemical function and neurotransmission, VMAT2 might be an important target for biological research in psychiatric disease including schizophrenia.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Research - Volume 68, Issue 2, October 2010, Pages 125-130
Journal: Neuroscience Research - Volume 68, Issue 2, October 2010, Pages 125-130
نویسندگان
Shuji Iritani, Hirotaka Sekiguchi, Chikako Habuchi, Youta Torii, Shinnosuke Yamada, Yukari Waki, Yukihiro Noda, Hiroshi Furukawa, Toshitaka Nabeshima, Norio Ozaki,