کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4353998 | 1298536 | 2007 | 21 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Stress during development: Impact on neuroplasticity and relevance to psychopathology
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کلمات کلیدی
PNDα-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acidFGF-2N-methyl-d-aspartateNMDAAMPABDNF - BDNF یا فاکتور نورونزایی مشتقشده از مغز Psychiatric disorder - اختلال روانیlong-term potentiation - تقویت درازمدتLTP - تقویت طولانی مدت یا LTP postnatal day - روز پس از زایمانbrain derived neurotrophic factor - عامل مغز استخوان مغز استخوان استbasic fibroblast growth factor - فاکتور رشد فیبروبلاست پایهprefrontal cortex - قشر prefrontalHPA - میلی بار یا هکتوپاسکالNeurotrophins - نوروتروفین Neurogenesis - نوروژنزhypothalamus-pituitary-adrenal - هیپوتالاموس-هیپوفیز-آدرنالHippocampus - هیپوکامپ glutamate - گلوتامات
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Development represents a critical moment for shaping adult behavior and may set the stage to disease vulnerability later in life. There is now compelling evidence that stressful experiences during gestation or early in life can lead to enhanced susceptibility for mental illness. In this paper we review the data from experimental studies aimed at investigating behavioral, hormonal, functional and molecular consequences of exposure to stressful events during prenatal or early postnatal life that might contribute to later psychopathology. The use of the newest methodology in the field and the intensive efforts produced by researchers have opened the possibility to reveal the complex, finely tuned and previously unappreciated sets of molecular interactions between different factors that are critical for neurodevelopment thus leading to important discoveries regarding perinatal life. The major focus of our work has been to revise and discuss data from animal studies supporting the role of neuronal plasticity in the long-term effects produced by developmental adversities on brain function as well as the possible implications for disease vulnerability. We believe these studies might prove useful for the identification of novel targets for more effective pharmacological treatments of mental illnesses.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Progress in Neurobiology - Volume 81, Issue 4, March 2007, Pages 197-217
Journal: Progress in Neurobiology - Volume 81, Issue 4, March 2007, Pages 197-217
نویسندگان
Fabio Fumagalli, Raffaella Molteni, Giorgio Racagni, Marco Andrea Riva,