Salicylate-induced cochlear impairments, cortical hyperactivity and re-tuning, and tinnitus

► Salicylate suppresses cochlear function selectively with less effect at mid-frequency. ► Salicylate enhances neural activity in auditory thalamus, cortex, and amygdala. ► Systemic salicylate application results in frequency map reorganization in the brain. ► More neurons turn to represent tinnitus frequency after systemic salicylate injection.