کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4371484 1302524 2008 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
In vitro trypanocidal activity of the anti-helminthic drug niclosamide
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی انگل شناسی
پیش نمایش صفحه اول مقاله
In vitro trypanocidal activity of the anti-helminthic drug niclosamide
چکیده انگلیسی

Only a few drugs are available for chemotherapy of African trypanosomiasis and there is an urgent need for the development of new anti-trypanosomal agents. In this study, the anti-helminthic drug niclosamide was tested for its trypanocidal activity in vitro using culture-adapted bloodstream forms of Trypanosoma brucei brucei and Trypanosoma congolense. The concentrations of niclosamide to reduce the growth rate by 50% and to kill all cells were in the low- and mid micromolar ranges for T. b. brucei and T. congolense, respectively. The very low toxicity of niclosamide for mammals makes the compound interesting for drug development for African trypanosomiasis.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Experimental Parasitology - Volume 118, Issue 4, April 2008, Pages 637–640
نویسندگان
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