کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4371782 1302540 2008 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Leishmania mexicana amazonensis: Plasma membrane adenine nucleotide translocator and chemotaxis
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی انگل شناسی
پیش نمایش صفحه اول مقاله
Leishmania mexicana amazonensis: Plasma membrane adenine nucleotide translocator and chemotaxis
چکیده انگلیسی

Leishmania cannot synthesize purines de novo and rely on their host to furnish these compounds. To accomplish this, they possess multiple purine nucleoside and nucleobase transporters. Subcellular fractionation, immunohistochemical localization with anti-adenine nucleotide translocator (ANT) antibodies and surface biotinylation show that the mitochondrial ANT is also present in the plasma membrane of both promastigotes and amastigotes. Leishmania, however, do not appear to rely on this transporter to supplement their purine or energy requirements via preformed ATP from its host. Rather, Leishmania appear to use the plasma membrane ANT as part of a chemotaxis response. ATP is a chemorepellent for Leishmania and cells treated with atractyloside, an inhibitor of ANT, no longer exhibit negative chemotaxis for this compound.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Experimental Parasitology - Volume 118, Issue 3, March 2008, Pages 408–419
نویسندگان
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