کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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4372225 | 1302588 | 2007 | 6 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Plasmodium berghei: In vitro and in vivo activity of dequalinium Plasmodium berghei: In vitro and in vivo activity of dequalinium](/preview/png/4372225.png)
Bisquinoline compounds have exhibited remarkable activity in vitro and in vivo against Plasmodium parasites by inhibition of heme detoxification. We have tested the ability of dequalinium 1,1′-(1,10-decanediyl)bis(4-amino-2-methylquinoline), a known antimicrobial agent, to inhibit β-hematin synthesis using a non-emzymatic colorimetric assay and globin proteolysis by electrophoretic analysis (SDS–PAGE-15%). Dequalinium was able to inhibit both processes in vitro with close correlation to a murine malaria model, reducing parasitemia levels, prolonging the survival time post-infection and curing 40% of infected mice using a combination therapy with a loading dose of chloroquine. These results confirm that dequalinium is a promising lead for antimalarial drug development.
Journal: Experimental Parasitology - Volume 115, Issue 1, January 2007, Pages 19–24