کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4407949 1618825 2016 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Emerging pollutants and plants - Metabolic activation of diclofenac by peroxidases
ترجمه فارسی عنوان
آلاینده ها و گیاهان در حال ظهور - فعال سازی متابولیک دیکلوفناک توسط پراکسیداز
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست شیمی زیست محیطی
چکیده انگلیسی
Human pharmaceuticals and their residues are constantly detected in our waterbodies, due to poor elimination rates, even in the most advanced waste water treatment plants. Their impact on the environment and human health still remains unclear. When phytoremediation is applied to aid water treatment, plants may transform and degrade xenobiotic contaminants through phase I and phase II metabolism to more water soluble and less toxic intermediates. In this context, peroxidases play a major role in activating compounds during phase I via oxidation. In the present work, the ability of a plant peroxidase to oxidize the human painkiller diclofenac was confirmed using stopped flow spectroscopy in combination with LC-MS analysis. Analysis of an orange colored product revealed the structure of the highly reactive Diclofenac-2,5-Iminoquinone, which may be the precursor of several biological conjugates and breakdown products in planta.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Chemosphere - Volume 146, March 2016, Pages 435-441
نویسندگان
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