کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4411617 1307601 2010 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Sorption of benzimidazole anthelmintics to dissolved organic matter surrogates and sewage sludge
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست شیمی زیست محیطی
پیش نمایش صفحه اول مقاله
Sorption of benzimidazole anthelmintics to dissolved organic matter surrogates and sewage sludge
چکیده انگلیسی

The sorption coefficients of four rarely studied zwitterionic pharmaceuticals (benzimidazoles: fenbendazole, albendazole, thiabendazole and flubendazole) and four metabolites of fenbendazole to various dissolved organic matter surrogates (humic acid, sodium dodecyl sulfate micelle, hydroxypropyl-β-cyclodextrin and liposomes made of 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC), and sewage sludge) were measured to extend the available sorption coefficients and eventually to evaluate their environmental fate in soil and water environment. For the entire range of dissolved organic matters, the more hydrophobic fenbendazole and albendazole had higher sorption coefficients than thiabendazole and flubendazole, indicating that the traditional hypothesis of hydrophobic interaction holds for zwitterionic benzimidazole anthelmintics. However, the sorption coefficients of a given benzimidazole to selected dissolved organic matters (DOMs) varied within an order of magnitude. The measured Koc values decreased in the order of fenbendazole, albendazole, thiabendazole and flubendazole for sewage sludge and hydroxypropyl-β-cyclodextrin whereas the orders were different for the other DOM surrogates, implying the hydrophilic nature of sewage sludge. This was also supported by the (N + O)/C elemental ratio of the sewage sludge sample used in this study. The correlations between log Koc and log Kow were weak (r2 = 0.28–0.64) and the magnitude of the sorption coefficients to the hydrophilic organic matters (hydroxypropyl-β-cyclodextrin and sewage sludge) were similar to or slightly smaller than those for the hydrophobic organic matters (humic acids and liposome). This suggests that specific hydrophilic interactions also play a significant role in the sorption of moderately hydrophobic benzimidazoles to organic matters.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Chemosphere - Volume 80, Issue 3, June 2010, Pages 256–262
نویسندگان
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