Quantum-chemical descriptors for estimating hemolytic activity of aliphatic and aromatic methacrylates

Methacrylates such as methyl methacrylate (6), triethyleneglycol dimethacrylate (5) and bisphenol A glycidyldimethacrylate, bis-GMA, (8) are widely used as materials in dental resins perturbation of the phosphatidylcholine–cholesterol interaction. Such effects of aromatic methacrylates may be involved in their marked hemolytic action.