کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4416652 1307792 2006 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Biotransformation of the flame retardant tetrabromo-bisphenol A by human and rat sub-cellular liver fractions
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست شیمی زیست محیطی
پیش نمایش صفحه اول مقاله
Biotransformation of the flame retardant tetrabromo-bisphenol A by human and rat sub-cellular liver fractions
چکیده انگلیسی

The comparative in vitro metabolism of the flame retardant tetrabromo-bisphenol A was studied in rat and human using a [14C]-radio-labelled molecule. Tetrabromo-bisphenol A is metabolised into the corresponding glucuronide (liver S9 fractions) and several other metabolites produced by cytochrome P450 dependent pathways (liver microsomes and liver S9 fractions). No major qualitative differences were observed between rat and human, regardless of the selected concentration, within the 20–200 μM range. Tetrabromo-bisphenol A undergoes an oxidative cleavage near the central carbon of the molecule, that leads to the production of hydroxylated dibromo-phenol, hydroxylated dibromo-isopropyl-phenol and glutathione conjugated dibromo-isopropyl-phenol. The main metabolites of tetrabromo-bisphenol A are two molecules of lower polarity than the parent compound, characterised as a hexa-brominated compound with three aromatic rings and a hepta-brominated dimer-like compound, respectively. Both structures, as well as the lower molecular weight metabolites resulting from the breakdown of the molecule, suggest the occurrence of chemically reactive intermediates formed following a first step oxidation of tetrabromo-bisphenol A.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Chemosphere - Volume 64, Issue 2, June 2006, Pages 318–327
نویسندگان
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