کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4420955 1618987 2012 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Assessment of the genotoxicity of quinolone and fluoroquinolones contaminated soil with the Vicia faba micronucleus test
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست شیمی زیست محیطی
پیش نمایش صفحه اول مقاله
Assessment of the genotoxicity of quinolone and fluoroquinolones contaminated soil with the Vicia faba micronucleus test
چکیده انگلیسی

The genotoxicity of quinolone and fluroquinolones was assessed using the micronucleus (MN) test on Vicia faba roots by direct contact exposure to a solid matrix. Plants were exposed to quinolones (nalidixic acid) and fluoroquinolones (ciprofloxacin and enrofloxacin) alone or mixed with artificially contaminated soils. Four different concentrations of each of these antibiotics were tested (0.01, 0.1, 1 and 10 mg/Kg) for nalidixic acid and (0.005, 0.05, 0.5 and 5 mg/Kg) for ciprofloxacin and enrofloxacin. These antibiotics were also used in mixture. Exposure of Vicia faba plants to each antibiotic at the highest two concentrations showed significant MN induction. The lowest two concentrations had no significant genotoxic effect. The mixture of the three compounds induced a significant MN induction whatever the mixture tested, from 0.02 to 20 mg/Kg. The results indicated that a similar genotoxic effect was obtained with the mixture at 0.2 mg/Kg in comparison with each molecule alone at 5–10 mg/Kg. Data revealed a clear synergism of these molecules on Vicia faba genotoxicity.


► This work demonstrated the genotoxicity of nalidixic acid, ciprofloxacin and enrofloxacin.
► Results revealed the high sensitivity of the Vicia faba micronucleus test to these chemicals.
► This study also suggests a strong synergism between the three molecules at very low concentrations.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Ecotoxicology and Environmental Safety - Volume 76, 1 February 2012, Pages 187–192
نویسندگان
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