کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4423255 | 1308817 | 2011 | 7 صفحه PDF | دانلود رایگان |

A set of biochemical and histological responses was measured in wild gudgeon collected upstream and downstream of urban and pharmaceutical manufacture effluents. These individual end-points were associated to fish assemblage characterisation. Responses of biotransformation enzymes, neurotoxicity and endocrine disruption biomarkers revealed contamination of investigated stream by a mixture of pollutants. Fish from sampled sites downstream of the industrial effluent exhibited also strong signs of endocrine disruption including vitellogenin induction, intersex and male-biased sex-ratio. These individual effects were associated to a decrease of density and a lack of sensitive fish species. This evidence supports the hypothesis that pharmaceutical compounds discharged in stream are involved in recorded endocrine disruption effects and fish population disturbances and threaten disappearance of resident fish species. Overall, this study gives argument for the utilisation of an effect-based monitoring approach to assess impacts of pharmaceutical manufacture discharges on wild fish populations.
Research highlights
► We assess individual and population effects downstream from pharmaceutical factory discharge.
► High concentration of vitellogenin and severe intesex were observed in fish living downstream from industrial effluent.
► Male-biased sex ratio and fish population disturbance were observed in downstream sites.
► Results of this work argue for specific monitoring of pharmaceutical manufacture discharges.
Journal: Environment International - Volume 37, Issue 8, November 2011, Pages 1342–1348