کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4424375 | 1619177 | 2014 | 7 صفحه PDF | دانلود رایگان |
• We studied the link between pollutants in human fat and serum lipids/obesity.
• Persistent pesticides and PCBs showed quadratic associations with serum lipids.
• Persistent pesticides also evidenced quadratic associations with obesity.
• PCB 138 was positively associated with obesity in a linear manner.
The aim of this research was to study the association of the accumulated human exposure to persistent organic pollutants with serum lipid levels and obesity, in a cohort of 298 adults.In the multivariable analyses, HCB concentrations evidenced a significant quadratic association with levels of total cholesterol, HDL, LDL, and total serum lipids. Likewise, PCBs 138 and 180 were associated with triglycerides and total serum lipids, and PCB 153 with LDL. HCB, p,p′-DDE, and β-HCH showed quadratic associations with BMI. All quadratic models showed a positive trend at low exposure levels, while the slope decreased or even became negative at higher exposure levels. Additionally, PCB 138 was positively associated with BMI but in a linear manner. Our results suggest a potential relationship between historical POP exposure and serum lipids/obesity, which followed a non-linear pattern in most cases.
Journal: Environmental Pollution - Volume 195, December 2014, Pages 9–15