کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4431147 | 1619862 | 2010 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Carcinogenic potential of endosulfan and its metabolites based on a quantum chemical model
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موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
شیمی زیست محیطی
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چکیده انگلیسی
The aim of the present study was to investigate the carcinogenic potential of endosulfan and its metabolites through electronic parameters that characterize the action of carcinogens, i.e. descriptors such as electron affinity, Δ (HOMO–LUMO), dipole moments, electrostatic attraction, formation heat (Hf) and permeability of the cell membrane (c Log P). The results reveal that both endosulfan and its metabolites are electrophilic and have carcinogenic potential. Although there are few data on its carcinogenicity in the literature, the findings of the present study indicate that the use of this pesticide represents a risk to the health of the general population, especially rural workers.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Science of The Total Environment - Volume 408, Issue 24, 15 November 2010, Pages 6281–6284
Journal: Science of The Total Environment - Volume 408, Issue 24, 15 November 2010, Pages 6281–6284
نویسندگان
C.N.G. Bedor, R.J.L. Morais, L.S. Cavalcanti, J.V. Ferreira, A.C. Pavão,