کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
444 42 2014 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Biodegradable Fe-based alloys for use in osteosynthesis: Outcome of an in vivo study after 52 weeks
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی بیو مهندسی (مهندسی زیستی)
پیش نمایش صفحه اول مقاله
Biodegradable Fe-based alloys for use in osteosynthesis: Outcome of an in vivo study after 52 weeks
چکیده انگلیسی

This study investigates the degradation performance of three Fe-based materials in a growing rat skeleton over a period of 1 year. Pins of pure Fe and two Fe-based alloys (Fe–10Mn–1Pd and Fe–21Mn–0.7C–1Pd, in wt.%) were implanted transcortically into the femur of 38 Sprague–Dawley rats and inspected after 4, 12, 24 and 52 weeks. The assessment was performed by ex vivo microfocus computed tomography, weight-loss determination, surface analysis of the explanted pins and histological examination. The materials investigated showed signs of degradation; however, the degradation proceeded rather slowly and no significant differences between the materials were detected. We discuss these unexpected findings on the basis of fundamental considerations regarding iron corrosion. Dense layers of degradation products were formed on the implants’ surfaces, and act as barriers against oxygen transport. For the degradation of iron, however, the presence of oxygen is an indispensable prerequisite. Its availability is generally a critical factor in bony tissue and rather limited there, i.e. in the vicinity of our implants. Because of the relatively slow degradation of both pure Fe and the Fe-based alloys, their suitability for bulk temporary implants such as those in osteosynthesis applications appears questionable.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Acta Biomaterialia - Volume 10, Issue 7, July 2014, Pages 3346–3353
نویسندگان
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