کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4458542 1620962 2006 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Effects of enhanced zinc and copper in drinking water on spatial memory and fear conditioning
موضوعات مرتبط
مهندسی و علوم پایه علوم زمین و سیارات زمین شناسی اقتصادی
پیش نمایش صفحه اول مقاله
Effects of enhanced zinc and copper in drinking water on spatial memory and fear conditioning
چکیده انگلیسی

Ingestion of enhanced zinc can cause memory impairments and copper deficiencies. This study examined the effect of zinc supplementation, with and without copper, on two types of memory. Rats raised pre- and post-natally on 10 mg/kg ZnCO3 or ZnSO4 in the drinking water were tested in a fear-conditioning experiment at 11 months of age. Both zinc groups showed a maladaptive retention of fearful memories compared to controls raised on tap water. Rats raised on 10 mg/kg ZnCO3, 10 mg/kg ZnCO3 + 0.25 mg/kg CuCl2, or tap water, were tested for spatial memory ability at 3 months of age. Significant improvements in performance were found in the ZnCO3 + CuCl2 group compared to the ZnCO3 group, suggesting that some of the cognitive deficits associated with zinc supplementation may be remediated by addition of copper.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Geochemical Exploration - Volume 88, Issues 1–3, January–March 2006, Pages 91–94
نویسندگان
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