Batch kinetics and modelling of Pleuromutilin production by Pleurotus mutilis

The kinetics of Pleuromutilin production was studied in batch cultivation process at pH 7.5 and temperature 27 °C. An unstructured mathematical model was proposed to describe the batch culture kinetics. The Luedeking–Piret equation was proposed for Pleuromutilin production. The model parameters were evaluated by means of batch cultivation data. The proposed model describe well the observed experimental kinetics with respect to substrate, biomass and product formation. The model may be useful for optimization of Pleuromutilin production.