کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4497379 1318931 2010 14 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Random discrete competing events vs. dynamic bistable switches in cell proliferation in differentiation
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک علوم کشاورزی و بیولوژیک (عمومی)
پیش نمایش صفحه اول مقاله
Random discrete competing events vs. dynamic bistable switches in cell proliferation in differentiation
چکیده انگلیسی
Several recent experiments related to fundamental aspects of cell behaviour, such as passing of the restriction point of cell cycle, which are generally interpreted in accordance with the dynamic paradigm implying the use of differential equations operating with the concentrations of cellular components and rate constants of their interactions, are shown in the present paper to be consistent with a simple model based on discrete competing stochastic events interpreted as assembly of alternative complexes of transcription factors at gene promoters. The model conforms to the transition probability model of cell cycle and to the stochastic approaches to cell differentiation and integrates them with the restriction point concept.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Theoretical Biology - Volume 267, Issue 3, 7 December 2010, Pages 341-354
نویسندگان
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