کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4500202 1319969 2013 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Stochastic disease dynamics of a hospital infection model
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک علوم کشاورزی و بیولوژیک (عمومی)
پیش نمایش صفحه اول مقاله
Stochastic disease dynamics of a hospital infection model
چکیده انگلیسی

A stochastic model for hospital infection incorporating both direct transmission and indirect transmission via free-living bacteria in the environment is investigated. We examine the long term behavior of the model by calculating a stationary distribution and normal approximation of the distribution. The quasi-stationary distribution of the model is studied to investigate the models’ behavior before extinction and the time to extinction. Numerical results show agreement between the calculated distributions and results of event-driven simulations. Hand hygiene of volunteers is more effective in terms of reducing the mean (or standard deviation) of the stationary distribution of colonized patients and the expected time to extinction compared to hand hygiene of health care workers (HCWs), on the basis of our parameter values. However, the indirect (or direct) transmission rate can lead to either increase or decrease in the standard deviation of the stationary distribution, but the impact of the indirect transmission is much greater than that of the direct transmission. The findings suggest that isolation of new admitted colonized patients is most effective in reducing both the mean and standard deviation of the stationary distribution and measures related to indirect transmission are secondary in their effects compared to other interventions.


► Isolation of new admitted colonized patients is the most effective measure.
► Hand hygiene of volunteers is more effective compared to hand hygiene of health care workers.
► Transmission rates can lead to increase or decrease in the standard deviation of colonized patients.
► Departure rate of patients contribute substantially to the expected time to extinction.
► The expected time to extinction may be different even if the basic reproduction number is the same.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Mathematical Biosciences - Volume 241, Issue 1, January 2013, Pages 115–124
نویسندگان
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