کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4500249 1624034 2012 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Social contact patterns and control strategies for influenza in the elderly
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک علوم کشاورزی و بیولوژیک (عمومی)
پیش نمایش صفحه اول مقاله
Social contact patterns and control strategies for influenza in the elderly
چکیده انگلیسی

Despite dramatic increases in influenza vaccination coverage in the elderly population over the past 30 years, influenza mortality rates have remained static in this age group. Children are believed to be the primary spreaders of diseases such as influenza due to their high degree of inter-contact in school settings, and several studies have examined control of influenza in the entire population, including the elderly, via targeted vaccination of school children. However, such vaccination programs are expensive, and fraught with difficulties of public perception of what may be seen as an unnecessary vaccination against a disease that is normally mild in the children themselves.In the study presented here, we examine the control of influenza in the elderly using simple social distancing measures during an influenza epidemic. The recent work of Glasser et al. characterizes daily contact interactions within the population in terms of preferential mixing between age group peers, co-workers, and parents and children. We expand upon this to include interactions between grandparents and grandchildren, and fit the parameters of this formulation to the recently published social contact survey data of Mossong et al. Using this formulation, we then model an influenza epidemic with an age-structured deterministic disease model and examine how reduction in contacts between grandchildren and grandparents affects the spread of influenza to the elderly.We find that over 50% of all influenza infections in the elderly are caused by direct contact with an infected child, and we determine that social distancing between grandparents and grandchildren is remarkably effective, and is capable of reducing influenza attack rates in the elderly by up to 60%.


► We model the effect of social distancing on influenza attack rates in the elderly.
► We find that 50% of influenza in elderly is caused by contact with an infected child.
► We thus examine the effect of grandparent/grandchild (g/c) social distancing.
► We find reduction in g/c interactions can reduce elder influenza attack rates by up to 60%.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Mathematical Biosciences - Volume 240, Issue 2, December 2012, Pages 241–249
نویسندگان
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