کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4500348 1319983 2011 14 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Analysis of a vaccine model with cross-immunity: When can two competing infectious strains coexist?
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک علوم کشاورزی و بیولوژیک (عمومی)
پیش نمایش صفحه اول مقاله
Analysis of a vaccine model with cross-immunity: When can two competing infectious strains coexist?
چکیده انگلیسی

We analyse here the vaccine model with cross-immunity proposed by Porco and Blower [1]. Porco and Blower [1] show that vaccination can shift the competitive balance in favour of a strain that, without vaccination, would be out-competed and that vaccination can also promote coexistence of different strains, something that normally is not expected [2]. Their results have been mainly obtained through numerical simulations, so that the conditions under which a shift in competitive balance or coexistence occurs have not been fully established. We give a rather complete description of its behaviour, at least in terms of equilibria. We find the exact conditions under which vaccination may lead to a shift in competitive balance and show that, under these conditions, there always exist a range of vaccination rates under which a coexistence equilibrium exists. We also find that a coexistence equilibrium exists (and is unstable) in a ‘bi-stability’ region, where both monomorphic equilibria are stable. This fact has been rarely observed in models of competition between pathogen strains.


► Analysis of a competition model between 2 strains with cross-immunity and vaccination.
► We find the exact conditions under which vaccination may lead to coexistence.
► There is a parameter region in which both monomorphic equilibria are stable.
► Possibility of observing hysteresis-type behaviour and sudden shift between strains.
► The model can be applied to other infectious diseases of S–I type (HPV for instance).

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Mathematical Biosciences - Volume 234, Issue 1, November 2011, Pages 33–46
نویسندگان
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