کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4500489 1319997 2010 15 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Models of cardiac excitation–contraction coupling in ventricular myocytes
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک علوم کشاورزی و بیولوژیک (عمومی)
پیش نمایش صفحه اول مقاله
Models of cardiac excitation–contraction coupling in ventricular myocytes
چکیده انگلیسی

Mathematical and computational modeling of cardiac excitation–contraction coupling has produced considerable insights into how the heart muscle contracts. With the increase in biophysical and physiological data available, the modeling has become more sophisticated with investigations spanning in scale from molecular components to whole cells. These modeling efforts have provided insight into cardiac excitation–contraction coupling that advanced and complemented experimental studies. One goal is to extend these detailed cellular models to model the whole heart. While this has been done with mechanical and electophysiological models, the complexity and fast time course of calcium dynamics have made inclusion of detailed calcium dynamics in whole heart models impractical. Novel methods such as the probability density approach and moment closure technique which increase computational efficiency might make this tractable.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Mathematical Biosciences - Volume 226, Issue 1, July 2010, Pages 1–15
نویسندگان
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