کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4500707 1320017 2009 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A systems-theoretical framework for health and disease: Inflammation and preconditioning from an abstract modeling point of view
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک علوم کشاورزی و بیولوژیک (عمومی)
پیش نمایش صفحه اول مقاله
A systems-theoretical framework for health and disease: Inflammation and preconditioning from an abstract modeling point of view
چکیده انگلیسی

Modern advances in molecular biology have produced enormous amounts of data characterizing physiological and disease states in cells and organisms. While bioinformatics has facilitated the organizing and mining of these data, it is the task of systems biology to merge the available information into dynamic, explanatory and predictive models. This article takes a step into this direction. It proposes a conceptual approach toward formalizing health and disease and illustrates it in the context of inflammation and preconditioning. Instead of defining health and disease states, the emphasis is on simplexes in a high-dimensional biomarker space. These simplexes are bounded by physiological constraints and permit the quantitative characterization of personalized health trajectories, health risk profiles that change with age, and the efficacy of different treatment options. The article mainly focuses on concepts but also briefly describes how the proposed concepts might be formulated rigorously within a mathematical framework.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Mathematical Biosciences - Volume 217, Issue 1, January 2009, Pages 11–18
نویسندگان
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