کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4500845 1320027 2008 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A mathematical model of oxygen transport in intact muscle with imposed surface oscillations
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک علوم کشاورزی و بیولوژیک (عمومی)
پیش نمایش صفحه اول مقاله
A mathematical model of oxygen transport in intact muscle with imposed surface oscillations
چکیده انگلیسی

A one-dimensional (1D) reaction–diffusion equation is presented to model oxygen delivery by the microcirculation and oxygen diffusion and consumption in intact muscle. This model is motivated by in vivo experiments in which oscillatory boundary conditions are used to study the mechanisms of local blood flow regulation in response to changes in the tissue oxygen environment. An exact periodic solution is presented for the 1D ‘in vivo’ model and shown to agree with experimental data for the case where the blood flow regulation system is not activated. Approximate low- and high-frequency solutions are presented, and the latter is shown to agree with the pure diffusion solution in the absence of sources or sinks. For the low frequencies considered experimentally, the 1D in vivo model shows that as depth increases: (i) the mean of tissue O2 oscillations changes exponentially, (ii) the amplitude of oscillations decreases very rapidly, and (iii) the phase of oscillations remains nearly the same as that of the imposed surface oscillations. The 1D in vivo model also shows that the dependence on depth of the mean, amplitude, and phase of tissue O2 oscillations is nearly the same for all stimulation periods >30 s, implying that experimentally varying the forcing period in this range will not change the spatial distribution of the O2 stimulation.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Mathematical Biosciences - Volume 213, Issue 1, May 2008, Pages 18–28
نویسندگان
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