کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4500870 | 1320029 | 2008 | 33 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Solvable models of neighbor-dependent substitution processes Solvable models of neighbor-dependent substitution processes](/preview/png/4500870.png)
We prove that a wide class of Markov models of neighbor-dependent substitution processes on the integer line is solvable. This class contains some models of nucleotidic substitutions recently introduced and studied empirically by molecular biologists. We show that the polynucleotidic frequencies at equilibrium solve some finite-size linear systems. This provides, for the first time up to our knowledge, explicit and algebraic formulas for the stationary frequencies of non-degenerate neighbor-dependent models of DNA substitutions. Furthermore, we show that the dynamics of these stochastic processes and their distribution at equilibrium exhibit some stringent, rather unexpected, independence properties. For example, nucleotidic sites at distance at least three evolve independently, and all the sites, when encoded as purines and pyrimidines, evolve independently.
Journal: Mathematical Biosciences - Volume 211, Issue 1, January 2008, Pages 56–88