کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4502659 | 1320589 | 2009 | 10 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: The conditional ancestral selection graph with strong balancing selection The conditional ancestral selection graph with strong balancing selection](/preview/png/4502659.png)
Using a heuristic separation-of-time-scales argument, we describe the behavior of the conditional ancestral selection graph with very strong balancing selection between a pair of alleles. In the limit as the strength of selection tends to infinity, we find that the ancestral process converges to a neutral structured coalescent, with two subpopulations representing the two alleles and mutation playing the role of migration. This agrees with a previous result of Kaplan et al., obtained using a different approach. We present the results of computer simulations to support our heuristic mathematical results. We also present a more rigorous demonstration that the neutral conditional ancestral process converges to the Kingman coalescent in the limit as the mutation rate tends to infinity.
Journal: Theoretical Population Biology - Volume 75, Issue 4, June 2009, Pages 355–364