کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
471956 698675 2016 14 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Feedback control of the immune response of renal transplant recipients with inequality constraints
ترجمه فارسی عنوان
کنترل بازخورد پاسخ ایمنی دریافت کنندگان پیوند کلیه با محدودیت های نابرابری
موضوعات مرتبط
مهندسی و علوم پایه مهندسی کامپیوتر علوم کامپیوتر (عمومی)
چکیده انگلیسی

This paper describes a model of the immunologic response of latent viruses and a donor kidney in a renal transplant recipient. An optimal control problem with state variable inequality constraints is considered to maintain the balance between over-suppression where latent viruses are reactivated and under-suppression where the transplanted kidney is rejected. A feedback methodology based on the model predictive control (MPC) method is proposed to design (sub)optimal treatment regimes. In addition, the problem of implementing the MPC methodology and nonlinear Kalman filter with inaccurate or incomplete observation data and long measurement periods is addressed. The results of numerical simulations show that a (sub)optimal dynamic immunosuppression therapy method can help strike a balance between the over-suppression and under-suppression of the immune system.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Computers & Mathematics with Applications - Volume 71, Issue 11, June 2016, Pages 2338–2351
نویسندگان
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