کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4752546 | 1361332 | 2017 | 42 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Prostate cancer diagnostics: Clinical challenges and the ongoing need for disruptive and effective diagnostic tools
ترجمه فارسی عنوان
تشخیص سرطان پروستات: چالش های بالینی و نیاز مداوم به ابزار تشخیصی مخرب و موثر
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کلمات کلیدی
سرطان پروستات، آزمایشهای تشخیصی سرطان پروستات تجاری، بیومارکرها، تاریخچه آنتی ژن خاص پروستات، چندگانه دستگاه های نقطه ای مراقبت،
موضوعات مرتبط
مهندسی و علوم پایه
مهندسی شیمی
بیو مهندسی (مهندسی زیستی)
چکیده انگلیسی
The increased incidence and the significant health burden associated with carcinoma of the prostate have led to substantial changes in its diagnosis over the past century. Despite technological advancements, the management of prostate cancer has become progressively more complex and controversial for both early and late-stage disease. The limitations and potential harms associated with the use of prostate-specific antigen (PSA) as a diagnostic marker have stimulated significant investigation of numerous novel biomarkers that demonstrate varying capacities to detect prostate cancer and can decrease unnecessary biopsies. However, only a few of these markers have been approved for specific clinical settings while the others have not been adequately validated for use. This review systematically and critically assesses ongoing issues and emerging challenges in the current state of prostate cancer diagnostic tools and the need for disruptive next generation tools based on analysis of combinations of these biomarkers to enhance predictive accuracy which will benefit clinical diagnostics and patient welfare.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biotechnology Advances - Volume 35, Issue 2, MarchâApril 2017, Pages 135-149
Journal: Biotechnology Advances - Volume 35, Issue 2, MarchâApril 2017, Pages 135-149
نویسندگان
Shikha Sharma, Julia Zapatero-RodrÃguez, Richard O'Kennedy,