کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4752627 | 1416278 | 2017 | 14 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
PECC: Correcting contigs based on paired-end read distribution
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موضوعات مرتبط
مهندسی و علوم پایه
مهندسی شیمی
بیو مهندسی (مهندسی زیستی)
پیش نمایش صفحه اول مقاله
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چکیده انگلیسی
In this paper, we propose a new method named “PECC” to identify and correct misassembly errors in contigs based on the paired-end read distribution. PECC extracts sequence regions with lower paired-end reads supports and verifies them based on the distribution of paired-end supports. To validate the effectiveness of PECC, we applied PECC to the contigs produced by five popular assemblers on four real datasets, and we also carried out experiments to analyze the influences of PECC on scaffolding. The results show that PECC can reduce misassembly errors and improve the performance of scaffolding results, which demonstrate the promising applications of PECC in de novo assembly.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Computational Biology and Chemistry - Volume 69, August 2017, Pages 178-184
Journal: Computational Biology and Chemistry - Volume 69, August 2017, Pages 178-184
نویسندگان
Min Li, Binbin Wu, Xiaodong Yan, Junwei Luo, Yi Pan, Fang-Xiang Wu, Jianxin Wang,