کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4763390 | 1422962 | 2017 | 18 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The first direct synthesis of chiral Tröger's bases catalyzed by chiral glucose-containing pyridinium ionic liquids
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
مهندسی شیمی
مهندسی شیمی (عمومی)
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چکیده انگلیسی
Tröger's base (TB) and its derivatives, especially chiral TBs are widely used in many fields. Although there is an urgent demand for the direct synthesis of pure enantiomers of TBs, convenient synthetic strategies are far less developed. Ionic liquids are green and recyclable solvent, therefore, in this paper, novel chiral glucose-containing pyridinium ionic liquids (1-((2S,3S,4R,5S,6S)-3,4,5-triacetoxy-6-(acetoxymethyl)tetrahydro-2H-pyran-2-yl)pyridin-1-ium tetrafluoroborate, [Py-G]+[BF4]â, 5) was synthesized and used as catalyst and solvent, while trifluoroacetic acid (TFA) was used as co-catalyst, to promote the one-step direct asymmetric synthesis of Tröger's bases with pyrazol flank (7) firstly at room temperature with high yields (up to 83%) and high ee value (up to 84%). A reasonable reaction mechanism was investigated by using chemical experiments, 1H NMR analysis and mass spectrometry. The novel method is environmental friendly and the result indicated its value of practical application.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Chemical Engineering Journal - Volume 316, 15 May 2017, Pages 1026-1034
Journal: Chemical Engineering Journal - Volume 316, 15 May 2017, Pages 1026-1034
نویسندگان
Rui Yuan, Yuan-jiang Wang, Yue Fang, Wen-hui Ge, Wei Lin, Ming-qi Li, Jiang-biao Xu, Yu Wan, Yun Liu, Hui Wu,