کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4768192 | 1424528 | 2016 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Solubility of water and acetone in hypromellose acetate succinate, HPMCAS-L
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
مهندسی شیمی
مهندسی شیمی (عمومی)
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چکیده انگلیسی
Thermodynamic properties of a hypromellose acetate succinate (HPMCAS-L)-acetone-water system at temperatures below the glass transition temperature of HPMCAS-L were investigated. The solubility of water and acetone in HPMCAS-L is important for the optimization of spray-drying processes used in pharmaceutical manufacturing of solid dispersion formulations. Finite concentration data of each component were obtained separately using gravimetric sorption, differential pressure decay, and capillary column inverse gas chromatography. Results of thermodynamic properties were compared with prediction models based on the UNIQUAC functional-group activity coefficients (UNIFAC) method as well as the correlation model of Flory-Huggins. UNIFAC interaction parameters, modified to account for the interactions of water with the monosaccharide type groups in HPMCAS-L, had to be used in order to generate reasonable predictions. Overall, the Flory-Huggins model provided the best representation for both binary systems.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Fluid Phase Equilibria - Volume 429, 15 December 2016, Pages 227-232
Journal: Fluid Phase Equilibria - Volume 429, 15 December 2016, Pages 227-232
نویسندگان
Derek R. Sturm, Sheng-Wei Chiu, Justin D. Moser, Ronald P. Danner,