Influence of electrolytes on liquid-liquid equilibria of water/1-butanol and on the partitioning of 5-hydroxymethylfurfural in water/1-butanol

Based on the LLE data, the partition coefficient KHMFw of HMF between 1-butanol and aqueous phase was determined. Li2SO4 caused a pronounced salting-out of HMF from the aqueous phase, whereas only a moderate influence was observed for NaCl and CH3COONa. LiCl even caused a salting-in at LiCl molalities above 6 mol/kgH2O. electrolyte Perturbed-Chain Statistical Associating Fluid Theory (ePC-SAFT) was successfully used to model the influence of salts on the LLE water/1-butanol. Without fitting parameters to LLE data of the quaternary system water/1-butanol/HMF/salt, ePC-SAFT allowed predicting the salt influence on the partitioning of HMF in these systems in good agreement with the experimental data.