Thermodynamic study of solubility for pyrazinamide in ten solvents from TÂ =Â (283.15 to 323.15) K

The solubility of pyrazinamide in ten solvents (water, methanol, ethanol, 1-propanol, 2-propanol, 1-butanol, 2-butanol, acetone, acetonitrile and ethyl acetate) at temperatures ranging from (278.15 to 323.15) K was determined by using the gravimetric method. The experimental results indicated that in different solvents, the solubility of pyrazinamide was temperature dependent and increased with the increasing temperature. Besides, the modified Apelblat equation, λh equation, Wilson model and NRTL model were employed to correlate the solubility data in the solvents. The results show that the correlated data are in good agreement with the experimental solubility. Furthermore, the mixing thermodynamic properties of pyrazinamide in different solvents were calculated based on the Wilson model. The outcome indicates that the mixing process of pyrazinamide is endothermic.