Statistical optimization of xylanase production from new isolated Penicillium oxalicum ZH-30 in submerged fermentation

This research aimed at optimizing fermentation condition (initial pH and temperature) of xylanase production from Penicillium oxalicum ZH-30 by statistical analysis using response surface methodology. Statistical analysis of results showed that the linear, quadric terms and interaction of these two variables had significant effects. The optimal conditions for higher production of xylanase were: initial pH 7.38 and temperature = 31.1 °C. The predicted and verified xylanase activities under optimal condition were 14.33 and 14.50 U/mL, respectively. The temperature range suitable for the industrial application of xylanase from P. oxalicum ZH-30 was 50–60 °C.