Determination and correlation of solubility of 11α,17α-dihydroxy-4-pregnene-3,20-dione in different solvents

The solubility of 11α,17α-dihydroxy-4-pregnene-3,20-dione in six pure solvents and two binary solvent mixtures was experimentally determined within the temperature range from 278.15 K to 313.15 K by using a synthetic method. The Modified Apelblat model, λh model, Van't Hoff model and the two Local composition models of Wilson model and NRTL model were used to correlate the experimental solubility in the pure solvents. The Modified Apelblat model, the CNIBS/R-K model and Jouyban-Acree model were successfully used to correlate the solubility in two sets of binary solvent mixtures. The results reveal that the solubility of 11α,17α-dihydroxy-4-pregnene-3,20-dione increases with increasing temperature in all solvents selected. In addition, the dissolution thermodynamic properties of 11α,17α-dihydroxy-4-pregnene-3,20-dione in different solvents were also calculated based on the NRTL model and experimental solubility.