Label-free electrochemical detection of RNA based on “Y” junction structure and restriction endonuclease-aided target recycling strategy

A label-free electrochemical biosensor for ultrasensitive let-7d RNA detection was developed based on nicking endonuclease (NEase) assisted template enhanced hybridization process (TEHP) and rolling circle amplification (RCA) induced formation of G-quadruplex-hemin complexes.107