Walking away from depression-motor activity increases ratings of mood and incentive drive in patients with major depression

Motor activity was measured with actigraphy in 12 patients with depression for one week. Severity of depression was assessed before and at the end of the study with depression rating scales. The patients reported mood and incentive drive once per hour. With lag sequential analysis, the temporal relationship between motor activity and mood and incentive drive was evaluated. Higher motor activity was associated with depression improvement. Motor activity had an acute association with mood and incentive drive, especially one hour after activity. The results support the Lewinsohn's model of depression and underline the impact of behavioural activation in antidepressant treatment.