کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4934587 | 1433967 | 2017 | 41 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Differential cytokine levels between early withdrawal and remission states in patients with alcohol dependence
ترجمه فارسی عنوان
سطوح دیفرانسیل سیتوکین در بیماران مبتلا به وابستگی به الکل در بین موارد زودرس و بهبودی وضعیت
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کلمات کلیدی
infTNFYBOCSSchedule of Affective Disorder and Schizophrenia-LifetimeSADS-LDSM-IV-TRHDRSγ-GTTMTGM-CSFALTLPSTrail Making Test - آزمایش تستAST - آسپارتات ترانس آمینازAspartate aminotransferase - آسپارتات ترانس آمیناز یا AST Alanine aminotransferase - آلانین آمینوترانسفرازAbstinence - استعفایAlcohol - الکلinterferon - اینترفرونinterleukin - اینترلوکینANOVA - تحلیل واریانس Analysis of varianceone-way analysis of variance - تحلیل واریانس یک راههDiagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision - راهنمای تشخیصی و آماری اختلالات روانی، نسخه چهارم، ویرایش متنCytokine - سیتوکینbody mass index - شاخص توده بدنBMI - شاخص توده بدنیgranulocyte-macrophage colony-stimulating factor - عامل گرانولوسیت-ماکروفاژ colony-stimulating factortumor necrosis factor - فاکتور نکروز تومورlipopolysaccharide - لیپوپلی ساکاریدHamilton Depression Rating Scale - مقیاس رتبه بندی افسردگی همیلتونAlcohol dependence - وابستگی الکلیInflammatory response - واکنش التهابی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
علوم غدد
چکیده انگلیسی
Alcohol dependence (AD) leads to altered innate and adaptive immune responses, and frequently co-occurs with inflammation. Therefore, inflammatory cytokines potentially play a crucial role in the development of alcohol-related illnesses. This study evaluated changes in plasma cytokine concentrations, liver function, cravings, depression severity, and cognitive function in male patients with AD, during the course of an alcohol-detoxification program. A total of 78 male patients with AD were recruited for a conservative detoxification program; and cytokine levels, depressive score, and cognitive impairment applying the Trail Making Test (TMT) were evaluated during early withdrawal (baseline) and after 4 weeks of abstinence from alcohol. Healthy volunteers (86 males) were also recruited as controls. Inflammatory cytokine expression in all participants was assessed by multiplex magnetic bead assay. AD patients during early withdrawal demonstrated higher cytokine levels than the healthy controls (P â¤Â 0.001 for all cytokines). However, the levels of cytokine expression were significantly lower after 4 weeks of abstinence from alcohol (P â¤Â 0.001, except for IL-1β and IL-5). Higher liver function marker levels, depressive severity, and TMT times were observed in patients at the beginning of the detoxification program than in healthy controls. Fortunately, these functions significantly ameliorated after 4 weeks of abstinence. (P â¤Â 0.001). Levels of circulating cytokines, liver function, and cognitive function may markers of alcohol use disorder.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Psychoneuroendocrinology - Volume 76, February 2017, Pages 183-191
Journal: Psychoneuroendocrinology - Volume 76, February 2017, Pages 183-191
نویسندگان
Che-Hung Yen, Pei-Shen Ho, Yi-Wei Yeh, Chih-Sung Liang, Shin-Chang Kuo, Chang-Chih Huang, Chun-Yen Chen, Mei-Chen Shih, Kuo-Hsing Ma, Yueh-Feng Sung, Ru-Band Lu, San-Yuan (Professor and Attending Psychiatrist),