کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5000681 | 1460754 | 2017 | 6 صفحه PDF | دانلود رایگان |
- BDDE was for the first time employed in the determination of tadalafil.
- The cathodic pretreatment improved the sensibility for tadalafil.
- A very sensitive method was developed using SWV obtaining a LOD of 42.3 nmol Lâ1.
- Voltammetric method was not statistically different from the chromatographic one.
This work presents the development of a novel voltammetric method for a sensitive, simple, fast and eco-friendly determination of tadalafil (TDL) using a cathodically pretreated boron-doped diamond electrode (CP-BDDE). Using cyclic voltammetry of TDL, this drug presented one irreversible and well resolved oxidation process at 0.905 V (vs Ag/AgCl (KCl 3.0 mol Lâ1)) in Britton-Robinson buffer solution (pH 4.0). A scan rate study demonstrated that TDL transport toward CP-BDDE is diffusion controlled and one proton and one electron are involved in its electrooxidation. Employing square-wave voltammetry under optimized parameters, there was a linear dependence of peak current and TDL concentration in the range of 0.15-1.28 μmol Lâ1 with a detection limit of 19.5 nmol Lâ1. The proposed method was successfully applied in TDL determination in pharmaceutical formulations. The results obtained with the voltammetric method were not statistically different from the comparative spectrophotometric method, at a 95% confidence level.
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Journal: Diamond and Related Materials - Volume 77, August 2017, Pages 153-158