Regioselective hydroformylation of vinyl esters catalyzed by Rh(acac)(CO)2 with simple and efficient diphosphinite ligands

• An efficient protocol for hydroformylation of vinyl acetate was explored.
• Used diphosphinite ligand was more active and selective then conventional ligands.
• Various aliphatic, aromatic and higher vinyl esters were well tolerated.
• Good conversion, excellent regio- and chemo-selectivity with high TON were achieved.

Simple and efficient diphosphinite ligands were evaluated in rhodium catalyzed hydroformylation of vinyl acetate. The effect of various reaction variables like temperature, pressure, substrate/Rh ratio, P/Rh ratio, solvents, time and different types of phosphorous ligands were studied. The diphosphinite ligand exhibited a considerable impact on the hydroformylation of vinyl esters and provided good turnover number (up to 10,000) with excellent regioselectivity (99%) to branched aldehyde. Wide range of vinyl esters including long chain aliphatic vinyl esters (up to C18) were well tolerated to provide good to excellent yield of desired product.

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