کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5030839 1470936 2017 18 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
New potentiometric sensor based on molecularly imprinted nanoparticles for cocaine detection
ترجمه فارسی عنوان
سنسور پتانسیومتری جدید مبتنی بر نانوذرات مولکولی برای تشخیص کوکائین است
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
چکیده انگلیسی
Here we present a potentiometric sensor for cocaine detection based on molecularly imprinted polymer nanoparticles (nanoMIPs) produced by the solid-phase imprinting method. The composition of polymers with high affinity for cocaine was optimised using molecular modelling. Four compositions were selected and polymers prepared using two protocols: chemical polymerisation in water and UV-initiated polymerisation in organic solvent. All synthesised nanoparticles had very good affinity to cocaine with dissociation constants between 0.6 nM and 5.3 nM. Imprinted polymers produced in organic solvent using acrylamide as a functional monomer demonstrated the highest yield and affinity, and so were selected for further sensor development. For this, nanoparticles were incorporated within a PVC matrix which was then used to prepare an ion-selective membrane integrated with a potentiometric transducer. It was demonstrated that the sensor was able to quantify cocaine in blood serum samples in the range of concentrations between 1 nM and 1 mM.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biosensors and Bioelectronics - Volume 96, 15 October 2017, Pages 49-54
نویسندگان
, , , , , ,