کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5032704 1471130 2017 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Comparative assessment of intrinsic mechanical stimuli on knee cartilage and compressed agarose constructs
ترجمه فارسی عنوان
ارزیابی مقایسه ای از محرک های مکانیکی ذاتی بر روی غضروف زانو و آگارز فشرده
کلمات کلیدی
مدل های عنصر محدود تماس تیبوفومورال، فشار بخار، حداکثر فشار اصلی، سرعت سیال، مهندسی بافت،
موضوعات مرتبط
مهندسی و علوم پایه سایر رشته های مهندسی مهندسی پزشکی
چکیده انگلیسی
A well-established cue for improving the properties of tissue-engineered cartilage is mechanical stimulation. However, the explicit ranges of mechanical stimuli that correspond to favorable metabolic outcomes are elusive. Usually, these outcomes have only been associated with the applied strain and frequency, an oversimplification that can hide the fundamental relationship between the intrinsic mechanical stimuli and the metabolic outcomes. This highlights two important key issues: the firstly is related to the evaluation of the intrinsic mechanical stimuli of native cartilage; the second, assuming that the intrinsic mechanical stimuli will be important, deals with the ability to replicate them on the tissue-engineered constructs. This study quantifies and compares the volume of cartilage and agarose subjected to a given magnitude range of each intrinsic mechanical stimulus, through a numerical simulation of a patient-specific knee model coupled with experimental data of contact during the stance phase of gait, and agarose constructs under direct-dynamic compression. The results suggest that direct compression loading needs to be parameterized with time-dependence during the initial culture period in order to better reproduce each one of the intrinsic mechanical stimuli developed in the patient-specific cartilage. A loading regime which combines time periods of low compressive strain (5%) and frequency (0.5 Hz), in order to approach the maximal principal strain and fluid velocity stimulus of the patient-specific cartilage, with time periods of high compressive strain (20%) and frequency (3 Hz), in order to approach the pore pressure values, may be advantageous relatively to a single loading regime throughout the full culture period.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Medical Engineering & Physics - Volume 44, June 2017, Pages 87-93
نویسندگان
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