Functional response of novel bioprotective poloxamer-structured vesicles on inflamed skin

Gallic acid and resveratrol were co-loaded in new highly biocompatible bionanovesicles, which were developed using an eco-friendly preparation method. The obtained liposomes and glycerosomes were combined with poloxamer 407, which structurally modifies the formulations favoring the vesicle interconnections. These new vesicles were deeply characterized and tested as a novel approach to prevent and restore inflamed/damaged skin tissue. In vitro and in vivo tests underlined a good effectiveness of phenols loaded in poloxamer structured vesicles to promote the accumulation of the payload in the skin and to counteract TPA (phorbol ester) induced damages and inflammation in mouse.220