Nanoparticle passage through porcine jejunal mucus: Microfluidics and rheology

A family of sixteen fluorescent silica nanoparticles of different sizes (10, 50, 100 and 200 nm) and surface functionalizations (uncoated anionic, aminated cationic and PEG1000/2000ylated) were ranked on their mucopermeation capabilities with a micro-slide. Additional rheological experiments were performed to investigate the effects of these charged silica nanoparticles on the viscoelastic properties of porcine jejunal mucus. The systematic study provides important insights for further development of oral nanomedicines.107