Evaluation of antitumor activity and cardiac toxicity of a bone-targeted ph-sensitive liposomal formulation in a bone metastasis tumor model in mice

Bone-targeted alendronate-coated liposomes containing doxorubicin (SpHL-AL-DOX) provide increased uptake in bone metastases, higher antitumor activity, reduced cardiac toxicity and reduced mortality rate when compared to either free doxorubicin or untargeted liposomes.173