Biodistribution of negatively charged iron oxide nanoparticles (IONPs) in mice and enhanced brain delivery using lysophosphatidic acid (LPA)

LPA enhanced accumulation of EDT-IONPs in mice brain. The effect of LPA and magnetic field on IONP deposition in brain (a). Data are mean ± SEM, n = 4 mice. * represents P < 0.05. Transmission electron micrographs of EDT-IONPs in brain (b) with or without LPA treatment; arrows point towards IONPs. The capillary lumen (CL) in the brain micrographs are labeled to allow identification of capillary and surrounding cells.396