کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5042250 1474381 2017 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Evidence of a prominent genetic basis for associations between psychoneurometric traits and common mental disorders
ترجمه فارسی عنوان
شواهد پایه ژنتیکی برجسته برای پیوند بین صفات روان یورومتری و اختلالات روانی رایج
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب رفتاری
چکیده انگلیسی


- Focuses on RDoC traits of threat sensitivity and weak response inhibition
- Quantifies these traits as psychoneurometric composite variables
- Shows strong genetic basis to relations of these traits with clinical problems

Threat sensitivity (THT) and weak inhibitory control (or disinhibition; DIS) are trait constructs that relate to multiple types of psychopathology and can be assessed psychoneurometrically (i.e., using self-report and physiological indicators combined). However, to establish that psychoneurometric assessments of THT and DIS index biologically-based liabilities, it is important to clarify the etiologic bases of these variables and their associations with clinical problems. The current work addressed this important issue using data from a sample of identical and fraternal adult twins (N = 454). THT was quantified using a scale measure and three physiological indicators of emotional reactivity to visual aversive stimuli. DIS was operationalized using scores on two scale measures combined with two brain indicators from cognitive processing tasks. THT and DIS operationalized in these ways both showed appreciable heritability (0.45, 0.68), and genetic variance in these traits accounted for most of their phenotypic associations with fear, distress, and substance use disorder symptoms. Our findings suggest that, as indices of basic dispositional liabilities for multiple forms of psychopathology with direct links to neurophysiology, psychoneurometric assessments of THT and DIS represent novel and important targets for biologically-oriented research on psychopathology.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Psychophysiology - Volume 115, May 2017, Pages 4-12
نویسندگان
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