Palladium supported on amine-functionalized mesoporous silica: Highly efficient phosphine-free catalyst for alkyne–alkyne cross-coupling reaction

An amine-functionalized mesoporous silica SBA-15 supported palladium catalyst was prepared and characterized. For the first time, this supported palladium has been used as an efficient phosphine-free and reusable catalyst for the cross-coupling of haloalkynes with terminal alkynes. A variety of haloalkynes and aromatic/aliphatic terminal alkynes were selectively coupled to afford unsymmetrical 1,4-disubstituted 1,3-diynes in good yields.

Amine-functionalized mesoporous silica SBA-15 supported palladium was found to be an efficient phosphine-free and reusable catalyst for the cross-coupling reactions of various haloalkynes and terminal alkynes with high selectivity.Figure optionsDownload as PowerPoint slideHighlights
► Palladium supported amine-functionalized mesoporous silica catalyst was prepared.
► The catalyst exhibited high efficiency for alkyne–alkyne cross-coupling reaction.
► The phosphine-free catalyst showed a broad substrate scope with high selectivity.