کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5121826 1486844 2017 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Odds ratios deconstructed: A new way to understand and explain odds ratios as conditional risk ratios
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی سیاست های بهداشت و سلامت عمومی
پیش نمایش صفحه اول مقاله
Odds ratios deconstructed: A new way to understand and explain odds ratios as conditional risk ratios
چکیده انگلیسی

ObjectivesThe aim of this analysis was to provide an alternative derivation of the odds ratio (OR) to provide an intuitive meaning, freeing it from any mention of odds, which may make it a more useful concept for clinicians to use when describing treatment effect.Study Design and SettingBy examining the four possible combinations of treatment/control and corresponding outcomes, we considered the conditional risk ratio (RR, also known as relative risk) of an event with the treatment compared with an event with the control for pairs of patients for whom treatment and control would yield different results. Both matched and unmatched studies are considered.ResultsWe found that the OR could be derived as the RR of an outcome with treatment compared with an outcome with control conditional on the treatment and control resulting in different outcomes, thus providing a measure of the net benefit of treatment.ConclusionIt has been claimed that the OR comparing the effect of treatment vs. control does not have the same clinical interpretability as RR because it involves ratios of odds and so is difficult to explain in terms of patient numbers. This new derivation provides an interpretation of the OR as an RR but conditional on treatment and control resulting in different outcomes. This may help explain the reason ORs cause interpretation difficulties in practice. Moreover, the OR may be a more clinically useful parameter to patients because it deals with only those situations where the outcome differs between the two groups.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Clinical Epidemiology - Volume 82, February 2017, Pages 87-93
نویسندگان
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